Senior Research Associate -Process R&D
Syngene
Bengaluru,Karnataka,India
1d ago

Job purpose

To work on process development and synthesis of organic compounds.

Key Responsibilities :

  • Involvement in preparing the cost sheets for new RFP’s
  • Performing experiments by focusing robust process, scale up studies, engineering studies etc. to ensure the process is robust enough to scale up
  • Noticing criticality of the experiments and provide valuable feedback to improve the process in-order to avoiding the batch failure
  • Optimizing the chemical processes in terms of safety, robustness, and reproducibility to synthesize the target APIs for tox / clinical studies on pilot plant scale followed by large / commercial scale
  • Planning the lab experiments as per the Gantt chart to meet the timeline for the projects
  • Preparing the weekly update and sharing to the project leader
  • Effectively utilize the available equipment’s such as jacketed reactor, parallel synthesized, HPLC and RC1 to generate documents and optimization of PRD process to scalable process.
  • Identifying the process related impurities and developing a robust process in-order to control the impurity or rejecting the impurity by purification method
  • Ensuring 100% compliance in cGMP, GDP and data integrity
  • Generating documents such as use test, solubility, halting time stability, stress experiments etc. for TTD and BMR preparations
  • Interacting with AD team MoA transfer for IPC, intermediate / Finished product, and raw materials
  • Minimum number of experiments as per the organization requirements and generating data which should help to scale up of projects
  • Analyzing the regular in-process samples in analytical lab
  • Possess the knowledge and exposure to environment, health, and safety (EHS) practices
  • Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab / plant safety
  • Attend training on environment, health, and safety (EHS) measures imparted company
  • Educational Qualification : MSc in Organic Chemistry / Chemistry

    Experience :

    3-6 years post qualification relevant experience in Process Research and Scale up, preferably CRO background.

    Technical / functional Skills :

  • Knowledge in literature search
  • Knowledge on TLC, Column Chromatography and Crystallizations
  • Understand the progress of the reaction and laboratory safety practices, understand reaction mechanisms, and Named reactions
  • He should be able to handle the shift operations independently
  • Experience of handling hazardous chemicals like NBL, DIBAL-H and corrosive reagents.
  • Hands on experience of handling of API equipment’s like, Reactor, Centrifuge, Vacuum tray drier and Hydrogentaor.
  • Having knowledge about handling of regulatory audits and customer audits
  • Behavioral Skills :

  • Should have the capability to work in a team and ability to handle demonstrate a good team spirit.
  • While possessing a good ability to follow instruction should also demonstrate innovative in his / her approach, good communication skills.
  • Should be proactive while working on allotted responsibility.
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